Murine cytomegalovirus-induced immunosuppression
نویسندگان
چکیده
منابع مشابه
Intraocular viral replication after systemic murine cytomegalovirus infection requires immunosuppression.
PURPOSE Human cytomegalovirus retinitis is the most common blinding complication of acquired immune deficiency syndrome. However, the pathogenesis of the disease is poorly understood. The authors sought to characterize intraocular viral replication after systemic murine cytomegalovirus (MCMV) infection in the normal and immunosuppressed Balb/c mouse. METHODS Normal or immunosuppressed mice (4...
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It has been pointed out that immunosuppression with cytotoxic, nonsteroidal drugs is associated with the development of cytomeglovirus (CMV) infection after renal transplantation, and that without such immunosuppression infection may not occur (3). What is not known is whether immunosuppression alone, without other factors peculiar to the transplant recipient, can cause CMV infection. One appro...
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We report a 35-year-old female receiving natalizumab as monotherapy for multiple sclerosis who subsequently developed severe cytomegalovirus gastritis. As cytomegalovirus gastritis has not been previously described during natalizumab treatment, we discuss the biological plausibility of this potential association and avenues for further study.
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Macrophages (M ) are activated by IFN and are important cellular targets for infection by human and murine cytomegalovirus (MCMV), making it advantageous for CMVs to block IFN -induced M differentiation. We found that MCMV infection inhibited IFN regulation of many genes in M . MCMV infection blocked IFN responses at the level of transcription without blocking Janus kinase signal transducer and...
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METHODS. The left eyes of nonimmunosuppressed (non-IS) BALB/c mice, immunosuppressed (IS) BALB/c mice, TNFR1 / C57BL/6 mice, and wild-type C57BL/6 mice were inoculated with MCMV k181 by way of the supraciliary route. On postinoculation days 3, 7, and 10, injected eyes of non-IS control and IS experimental mice were removed for RT-PCR for TNFand TNFR1. Protein expression of TNF, caspase-8, and c...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1982
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.36.1.89-95.1982